5-TRANS U-44069 Chemical Properties

Boiling point:

519.7±35.0 °C(Predicted)

Density 

1.092±0.06 g/cm3(Predicted)

solubility 

DMF: >100 mg/ml (from U-46619); DMSO: >100 mg/ml (from U-46619); Ethanol: >100 mg/ml (from U-46619); PBS pH 7.2: >2 mg/ml (from U-46619)

pka

4.76±0.10(Predicted)

5-TRANS U-44069 Usage And Synthesis

Description

5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 . It inhibits microsomal prostaglandin E₂ synthase (mPGES) when used at a concentration of 10 μM.¹

References

1. Quraishi, O., Mancini, J.A., and Riendeau, D. Inhibition of inducible prostaglandin E₂ synthase by 15-deoxy-Δ^12,14-prostaglandin J₂ and polyunsaturated fatty acids Biochem. Pharmacol. 63(6),1183-1189(2002).