METHYL 2-BROMO-2-BUTENOATE Chemical Properties

Boiling point:

178-182 °C (lit.)

Density 

1.505 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.486

Flash point:

63 °C

storage temp. 

2-8°C

BRN 

1700999

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

8

MSDS

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METHYL 2-BROMO-2-BUTENOATE Usage And Synthesis

General Description

Methyl 2-bromo-2-butenoate(Methyl (Z)-2-bromocrotonate) yields (S)-2-bromobutanoic acid by baker′s yeast fermentation. It undergoes biotransformation catalyzed by old yellow enzyme to yield methyl (S)-2-bromobutanoate, a key intermediate for the synthesis of chiral drugs. It is a biannelating reagent which participates in double Michael-additions.

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