ALBORIXIN
ALBORIXIN Basic information
- Product Name:
- ALBORIXIN
- Synonyms:
-
- ALBORIXIN
- Antibiotic S-14750A
- 2H-Pyran-2-acetic acid, 6-[(2R,3S)-3-[(2R,5S,6R)-6-[[(2R,3S,5R,6R)-6-[(R)-[(2S,2'R,3'R,5S,5'S)-5'-[(2R,5R,6S)-6-ethyltetrahydro-5-hydroxy-5-methyl-2H-pyran-2-yl]octahydro-2'-hydroxy-2,3',5'-trimethyl[2,2'-bifuran]-5-yl]hydroxymethyl]tetrahydro-6-hydroxy-3,5-dimethyl-2H-pyran-2-yl]methyl]tetrahydro-6...
- CAS:
- 57760-36-8
- MF:
- C48H84O14
- MW:
- 885.17
- Mol File:
- 57760-36-8.mol
ALBORIXIN Chemical Properties
- Melting point:
- 100-105°
- alpha
- 20 -7° (c = 4 in acetone)
- Boiling point:
- 929.8±65.0 °C(Predicted)
- Density
- 1.157±0.06 g/cm3(Predicted)
- solubility
- Dichloromethane: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble - pka
- 10.02 (25° in methanol)
ALBORIXIN Usage And Synthesis
Uses
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease[1].
Definition
ChEBI: A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus.
References
[1] Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019 Oct;15(10):1810-1828. DOI:10.1080/15548627.2019.1596476
[2] C DELHOMME. Alborixin, a new antibiotic ionophore: taxonomy, isolation and biological properties.[J]. Journal of Antibiotics, 1976, 29 7: 692-695. DOI: 10.7164/antibiotics.29.692
[3] AABID MANZOOR SHAH . Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells[J]. Chemico-Biological Interactions, 2016, 256: Pages 198-208. DOI: 10.1016/j.cbi.2016.06.032
[4] N MOINS P D M P Gachon. Effects of two monocarboxylic ionophores, grisorixin and alborixin, on cardiovascular function and plasma cation concentrations in the anesthetized dog.[J]. Journal of Cardiovascular Pharmacology, 1979, 1 6: 659-671. DOI: 10.1097/00005344-197911000-00007
[5] B L BLAGBURN. Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.[J]. Antimicrobial Agents and Chemotherapy, 1991, 35 7: 1520-1523. DOI: 10.1128/aac.35.7.1520
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