3,4-DIAMINOBENZOTRIFLUORIDE Chemical Properties

Melting point:

56-58 °C

Boiling point:

253℃

Density 

1.381

Flash point:

111℃

storage temp. 

2-8°C(protect from light)

pka

2.94±0.10(Predicted)

form 

powder

color 

Light brown to brown

Water Solubility 

Miscible with water.

BRN 

909258

CAS DataBase Reference

368-71-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22-22

Safety Statements 

36/37/39-26

RIDADR 

2811

Hazard Note 

Harmful/Irritant

HazardClass 

IRRITANT-HARMFUL

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29215900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,4-DIAMINOBENZOTRIFLUORIDE Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

3,4-Diaminobenzotrifluoride is commonly used as pharmaceutical intermediate.

Synthesis

The reaction was carried out in anhydrous ethanol (50 mL) at reflux for 45 minutes with 4-amino-3-nitrobenzotrifluoride (5.000 g, 24.26 mmol, Aldrich, direct use) and SnCl2-2H2O (20.00 g, 88.64 mmol, Aldrich, direct use). Upon completion of the reaction, the mixture was poured into ice (85 g) and alkalized with 10% aqueous NaHCO3 (250 mL). Subsequently, the resulting suspension was extracted with ethyl acetate (400 mL). The ethyl acetate extracts were combined, dried with Na2SO4, and the solvent was evaporated under reduced pressure to give 4.14 g (87% yield) of pure 4-trifluoromethyl-1,2-phenylenediamine as a red powder.

References

[1] Patent: US5514680, 1996, A

3,4-DIAMINOBENZOTRIFLUORIDE(368-71-8)Related Product Information

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