(R)-3-Aminopyrrolidine Chemical Properties

Boiling point:

164-165 °C(lit.)

Density 

0.984 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.489(lit.)

Flash point:

147 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

clear liquid

pka

9.94±0.20(Predicted)

color 

Colorless to Almost colorless

optical activity

[α]/D +20°, neat

CAS DataBase Reference

116183-82-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

(R)-3-Aminopyrrolidine Usage And Synthesis

Synthesis

General procedure for the synthesis of (S)-3-aminopyrrolidine from (S)-1-benzyl-3-aminopyrrolidine: 7.0 g of (S)-1-benzyl-3-aminopyrrolidine, 25 mL of methanol, and 0.7 g of 5% Pd/C catalyst were added to a 100 mL autoclave. The hydrogen pressure was adjusted to 1 MPa, the temperature was raised to 70 °C and the reaction was kept stirring for 8 hours. Upon completion of the reaction, it was cooled to room temperature and the pressure was slowly released. The reaction mixture was filtered to remove the catalyst and the mother liquor was concentrated and purified by distillation to collect the 80-83 °C/40 kPa fraction to give 3.2 g of (S)-3-aminopyrrolidine. The product was analyzed with 99% chemical purity and 90% optical purity e.e.

References

[1] Patent: US6348600, 2002, B1. Location in patent: Page column 14
[2] Patent: EP1640364, 2006, A1. Location in patent: Page/Page column 10
[3] Patent: EP1236716, 2002, A1. Location in patent: Example 6

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