2-((3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-METHYLENE)-4-CYCLOPENTENE-1,3-DIONE Chemical Properties

Boiling point:

442.4±44.0 °C(Predicted)

Density 

1.137±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

Soluble in DMSO (10mg/ml)

form 

Yellow solid

pka

10.04±0.50(Predicted)

color 

yellow

InChI

1S/C20H24O3/c1-19(2,3)14-10-12(9-13-16(21)7-8-17(13)22)11-15(18(14)23)20(4,5)6/h7-11,23H,1-6H3

InChIKey

VUEUMQIBGLKJJD-UHFFFAOYSA-N

SMILES

Oc1c(cc(cc1C(C)(C)C)C=C2C(=O)C=CC2=O)C(C)(C)C

Safety Information

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

2-((3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-METHYLENE)-4-CYCLOPENTENE-1,3-DIONE Usage And Synthesis

Uses

TX-1123 is a protein tyrosine kinase inhibitor, having low mitochondrial toxicity and antitumor activity.

Biological Activity

Cell permeable: yes', 'Primary Target
Src', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 2.2, 3.2, and 9.6 μM against Src, eEF2-K, and PKA, respectively

IC 50

COX-2: 1.16 nM (IC₅₀); COX-1: 15.7 μM (IC₅₀)

storage

+4°C

2-((3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-METHYLENE)-4-CYCLOPENTENE-1,3-DIONE(157397-06-3)Related Product Information

• 4-CYCLOPENTENE-1,3-DIONE