1,3-PBIT DIHYDROBROMIDE Chemical Properties

storage temp. 

−20°C

form 

A crystalline solid

Water Solubility 

≤100mg/ml in Water

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

1,3-PBIT DIHYDROBROMIDE Usage And Synthesis

Uses

1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

References

[1] Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J. Biol. Chem. 269(43), 26669-26676 (1994).