PRATENSEIN
PRATENSEIN Basic information
- Product Name:
- PRATENSEIN
- Synonyms:
-
- 5,7,3'-Trihydroxy-4'-methoxyisoflavone
- 5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
- PATCHOULI ALCOHOL (RG)
- 4'-METHOXY-3',5,7-TRIHYDROXYISOFLAVONE
- PRATENSEIN
- PRALENREIN
- OROBOL 4'-METHYL ETHER
- Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cognitive,inhibit,BDNF,synapse,Pratensein,damage,impairment,NF-κB,oxidative
- CAS:
- 2284-31-3
- MF:
- C16H12O6
- MW:
- 300.26
- Product Categories:
-
- Iso-Flavones
- Mol File:
- 2284-31-3.mol
PRATENSEIN Chemical Properties
- Melting point:
- 272-273°
- Boiling point:
- 576.7±50.0 °C(Predicted)
- Density
- 1.512±0.06 g/cm3(Predicted)
- pka
- 6.45±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C16H12O6/c1-21-13-3-2-8(4-11(13)18)10-7-22-14-6-9(17)5-12(19)15(14)16(10)20/h2-7,17-19H,1H3
- InChIKey
- FPIOBTBNRZPWJW-UHFFFAOYSA-N
- SMILES
- C1OC2=CC(O)=CC(O)=C2C(=O)C=1C1=CC=C(OC)C(O)=C1
PRATENSEIN Usage And Synthesis
Uses
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].
Definition
ChEBI: A member of the class of 7-hydroxyisoflavones in which isoflavone is substituted by hydroxy groups at the 5, 7, and 3' positions, and by a methoxy group at the 4' position.
in vivo
Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1].
Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1].
| Animal Model: | Male 10-week old Wistar rats[1] |
| Dosage: | 20 mg/kg |
| Administration: | P.o.; once daily for 3 weeks |
| Result: | The spatial learning and memory ability of rats was improved. |
References
[1] Liang C, et al. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. Neurosci Lett. 2015;592:48-53. DOI:10.1016/j.neulet.2015.03.003
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PRATENSEIN(2284-31-3)Related Product Information
- PRATENSEIN(P)
- 5,7,3',4'-TETRAMETHOXYISOFLAVONE
- 5-HYDROXYDEQUELIN
- 5,7-DIHYDROXY-3-(2,4,5-TRIMETHOXY-PHENYL)-CHROMEN-4-ONE
- 5-HYDROXY-7-METHOXY-3-(2,4,5-TRIMETHOXY-PHENYL)-CHROMEN-4-ONE
- ISOPOMIFERIN-3',4'-DIMETHYL ETHER
- OROBOL 7,3',4'-TRIMETHYL ETHER
- OROBOL 7,4'-DIMETHYL ETHER
- POMIFERIN-3',4'-DIMETHYL ETHER
- 5-METHOXYMETHYLACICERONE
- 3'-O-METHYLPRATENSEIN
- IRISFLORENTIN
- PRATENSEIN
- 5,7-DIHYDROXY-3',4'-METHYLENEDIOXYISOFLAVONE
- 5-METHOXYDURMILLONE