1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties

Boiling point:

784.6±60.0 °C(Predicted)

Density 

1.426±0.06 g/cm3(Predicted)

pka

10.74±0.40(Predicted)

1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis

Uses

Thalidomide-NH-PEG4-MS is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

Biological Activity

Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1]. XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

IC 50

Cereblon

References

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-(2140807-24-3)Related Product Information

• Acetaldehyde, 2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-
• Thalidomide-NH-PEG6-OH
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-