4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE
4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE Basic information
- Product Name:
- 4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE
- Synonyms:
-
- 4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE
- CGH 2466 DIHYDROCHLORIDE
- 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolaminedihydrochloride
- 4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-thiazol-2-ylamine
- 2-Thiazolamine, 4-(3,4-dichlorophenyl)-5-(4-pyridinyl)-
- CAS:
- 252198-68-8
- MF:
- C14H9Cl2N3S
- MW:
- 322.21
- Mol File:
- 252198-68-8.mol
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4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE Chemical Properties
- storage temp.
- Desiccate at +4°C
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4-(3,4-DICHLOROPHENYL)-5-(4-PYRIDINYL)-2-THIAZOLAMINE Usage And Synthesis
Definition
ChEBI: CGH 2466 is a member of thiazoles.
Biological Activity
Adenosine A 1 , A 2B and A 3 receptor antagonist (IC 50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC 50 = 187-400 nM) and phosphodiesterase type 4D (IC 50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo . Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.