quinacillin
quinacillin Basic information
- Product Name:
- quinacillin
- Synonyms:
-
- 6α-[[3-(Sodiooxycarbonyl)quinoxalin-2-yl]carbonylamino]penicillanic acid sodium salt
- (2S,5R,6R)-6-[(3-carboxyquinoxalin-2-yl)carbonylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2S,5R,6R)-6-[(3-carboxyquinoxaline-2-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2S,5R,6R)-6-[(3-carboxyquinoxaline-2-carbonyl)amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- quinacillin
- 3-Carboxy-2-quinoxalinylpenicillanic acid
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(3-carboxy-2-quinoxalinyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
- CAS:
- 1596-63-0
- MF:
- C18H16N4O6S
- MW:
- 416.41
- EINECS:
- 216-481-7
- Mol File:
- 1596-63-0.mol
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quinacillin Usage And Synthesis
Uses
Quinacillin is a compound that undergoes hydrolysis catalyzed by penicillinase. Quinacillin is irreversibly covalently bound to proteins via its β-lactam carboxyl group[1].
Definition
ChEBI: Quinacillin is a semisynthetic penicillase-resistant penicillin with antibacterial activity; it binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. It has a role as an antibacterial drug. It is a penicillin and a quinoxaline derivative.
References
[1] Virden R, et al. The active site of penicillinase from Staphylococcus aureus PC1. Isolation of a specific covalent complex with the substrate quinacillin[J]. Biochemical Journal, 1975, 149(2): 397-401.
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