quinupramine
quinupramine Basic information
- Product Name:
- quinupramine
- Synonyms:
-
- quinupramine
- 10,11-Dihydro-5-(quinuclidin-3-yl)-5H-dibenz[b,f]azepine
- 10,11-Dihydro-5-(3-quinuclidinyl)-5H-dibenz(B,F)azepine
- 5-(3-Chinuclidinyl)-10,11-dihydro-5H-dibenz(B,F)azepin
- 5H-Dibenz(B,F)azepine, 10,11-dihydro-5-(3-quinuclidinyl)-
- Einecs 250-780-3
- Quinupramina
- Quinupramina [inn-spanish]
- CAS:
- 31721-17-2
- MF:
- C21H24N2
- MW:
- 304.43
- EINECS:
- 250-780-3
- Mol File:
- 31721-17-2.mol
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quinupramine Chemical Properties
- Melting point:
- 150°
- Boiling point:
- 445.2±44.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly, Sonicated)
- form
- Solid
- pka
- 10.00±0.33(Predicted)
- color
- Brown
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quinupramine Usage And Synthesis
Uses
Quinupramine is an analog of Imipramine (I465980). Quinupramine is used as an antidepressant.
Definition
ChEBI: Quinupramine is a dibenzooxazepine.
in vivo
Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat[2].
Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations[3].
| Animal Model: | Sprague-Dawley rats (Male, 220-270 g) |
| Dosage: | 10 mg/kg |
| Administration: | PO, twice daily for 10 days |
| Result: | Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain. |
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