4-iodophthalic acid Chemical Properties

Melting point:

180-184 °C

Boiling point:

431.1±40.0 °C(Predicted)

Density 

2.138±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.90±0.10(Predicted)

Appearance

White to off-white Solid

4-iodophthalic acid Usage And Synthesis

Synthesis Reference(s)

The Journal of Organic Chemistry, 16, p. 1275, 1951 DOI: 10.1021/jo50002a014

Synthesis

The general procedure for the synthesis of 4-iodophthalic acid from 3,4-dimethyl iodobenzene was as follows: 3,4-dimethyl iodobenzene (31 mL, 0.22 mol) was co-dissolved with pyridine (125 mL) in water (375 mL), and potassium permanganate (205 g, 1.3 mol) was slowly added at 60°C and reacted for 16 h under continuous stirring. After completion of the reaction, the temperature was maintained at 60°C and the filtrate was filtered through diatomaceous earth to remove solid impurities. After cooling the filtrate to room temperature, it was acidified by adjusting the pH to 2 with 6N hydrochloric acid and subsequently extracted with ethyl acetate. After purification by column chromatography, the target product 4-iodophthalic acid (44 g, 69% yield) was concentrated.

References

[1] Patent: KR2015/60183, 2015, A. Location in patent: Paragraph 0101; 0102; 0103
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 5919 - 5924

4-iodophthalic acid (6301-60-6)Related Product Information

• 4-IODO-2-METHYLBENZYL ALCOHOL
• 4-Iodo-1,2-dimethylbenzene
• 1,2-BENZENEDICARBOXYLIC ACID,4-IODO-,1,2-DIETHYL ESTER
• 5-Iodo-2-methylbenzoic acid
• 4-Iodobenzoic acid
• dimethyl 4-iodophthalate
• 4-iodophthalic acid
• 4,5-DIIODO-PHTHALIC ACID