Tebufelone
Tebufelone Basic information
- Product Name:
- Tebufelone
- Synonyms:
-
- Tebufelone
- 1-(3,5-Ditert-butyl-4-hydroxyphenyl)-5-hexyn-1-one
- NE-11740
- 5-Hexyn-1-one, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-
- Tebufelone, 10 mM in DMSO
- CAS:
- 112018-00-5
- MF:
- C20H28O2
- MW:
- 300.44
- Mol File:
- 112018-00-5.mol
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Tebufelone Chemical Properties
- form
- Solid
- color
- White to off-white
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Tebufelone Usage And Synthesis
Uses
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
IC 50
COX-2; 5-LO
References
[1] S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. DOI:10.1007/BF02001910
[2] Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206. DOI:10.1002/cmdc.202300206
TebufeloneSupplier
Shanghai Yifei Biotechnology Co. , Ltd.
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Yantai Shengkailun Chemical Technology Co., Ltd.
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RD International Technology Co., Limited
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TargetMol Chemicals Inc.
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