3-Pyridinesulfonamide,6-amino-(7CI,9CI) Chemical Properties

Melting point:

175.0-176.5 °C

Boiling point:

432.8±55.0 °C(Predicted)

Density 

1.520±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

pka

9.46±0.60(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

3-Pyridinesulfonamide,6-amino-(7CI,9CI) Usage And Synthesis

Synthesis

Example 34 Synthesis of 3-[7-fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-N-(5-aminosulfonylpyridin-2-yl)propanamide A. Preparation of 6-aminopyridine-3-sulfonamide 6-Chloropyridine-3-sulfonamide (200 mg, 1 mmol) was placed in a sealed tube and 2 mL of 28% aqueous ammonia solution was added. The reaction mixture was heated to 110°C and kept for 4 hours. After completion of the reaction, the mixture was diluted with brine and 6-aminopyridine-3-sulfonamide was collected by filtration to give a white solid (120 mg, 67% yield).

References

[1] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 44
[2] Bulletin de la Societe Chimique de France, 1939, vol. <5> 6, p. 736,738

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