dihydronovobiocin Chemical Properties

Boiling point:

658.4°C (rough estimate)

Density 

1.2955 (rough estimate)

refractive index 

1.5800 (estimate)

storage temp. 

Store at -20°C

solubility 

DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

A solid

Water Solubility 

0.18g/L(28 ºC)

dihydronovobiocin Usage And Synthesis

Uses

Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections[1][2].

References

[1] Gormley NA, et al. The interaction of coumarin antibiotics with fragments of DNA gyrase B protein. Biochemistry. 1996 Apr 16;35(15):5083-92. DOI:10.1021/bi952888n
[2] Oram M, et al. Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. Antimicrob Agents Chemother. 1996 Feb;40(2):473-6. DOI:10.1128/AAC.40.2.473

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