tolmetin glucuronide Chemical Properties

Melting point:

139-142°C

Boiling point:

706.1±60.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

2.68±0.70(Predicted)

color 

White to Brown

Stability:

Hygroscopic

tolmetin glucuronide Usage And Synthesis

Description

Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin . Tolmetin β-D-glucuronide has been classified into a ‘warning’ category in terms of its potential to cause idiosyncratic drug toxicity, based on its half-life in several in vitro systems.

Chemical Properties

Beige Solid

Uses

A metabolite of Tolmetin.

Definition

ChEBI: Tolmetin glucuronide is a glucosiduronic acid.

References

[1] MARTHA L. HYNECK . High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1987, 420: Pages 349-356. DOI: 10.1016/0378-4347(87)80190-1
[2] RYOKO SAWAMURA. Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.[J]. Drug Metabolism and Disposition, 2010, 38 10: 1857-1864. DOI: 10.1124/dmd.110.034173

tolmetin glucuronide(71595-19-2)Related Product Information

• Tolmetin