AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2
AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2 Basic information
- Product Name:
- AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2
- Synonyms:
-
- AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2
- Ac-AE-Asp(EDANS)-EE-Abu-L-lactoyl-S-Lys(DABCYL)-NH2
- Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-L-lactoyl-Ser-Lys(DABCYL)-NH2 ammonium salt
- N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-(2S)-2-aminobutanoyl-(2S)-2-hydroxypropanoyl-L-seryl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-lysinamide
- L-Lysinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-(2S)-2-aminobutanoyl-(2S)-2-hydroxypropanoyl-L-seryl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-
- CAS:
- 188530-20-3
- MF:
- C68H89N15O25S
- MW:
- 1548.58
- Mol File:
- 188530-20-3.mol
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AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2 Chemical Properties
- Density
- 1.49±0.1 g/cm3(Predicted)
- pka
- -0.26±0.40(Predicted)
- Sequence
- Ac-Asp-Glu-{Asp(Edans)}-Glu-Glu-Abu-{ψ-(COO)Ala}-Ser-{Lys(Dabcyl)}-NH2
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AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2 Usage And Synthesis
Uses
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 355/500 nm.)
AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2Supplier
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