GYKI 46903
GYKI 46903 Basic information
- Product Name:
- GYKI 46903
- Synonyms:
-
- GYKI 46903
- GYKI-46903 HCl
- 903
- GYKI 46
- GYKI46
- GYKI-46
- GYKI 46903 HCl,GYKI46903 HCl
- CAS:
- 142999-59-5
- MF:
- C17H21ClFNO2
- MW:
- 325.81
- Mol File:
- 142999-59-5.mol
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GYKI 46903 Usage And Synthesis
Description
GYKI-46903 is a non-competitive antagonist for 5-HT3 receptors. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. GYKI-46903, when administered by intravenous infusion, antagonized the decrease in heart rate evoked by serotonin (Bezold-Jarisch reflex) in anaesthetized rats, and the maximal reversal was less than 50%.