BMY 25368 Chemical Properties

Boiling point:

501.4±60.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

pka

8.97±0.10(Predicted)

BMY 25368 Usage And Synthesis

Uses

BMY-25368 (SKF 94482) is a histamine H2 receptor antagonist that acts as a gastric acid secretion inhibitor. BMY-25368 competitively antagonizes gastric secretion stimulated by histamine and also antagonizes gastric secretion stimulated by Pentagastrin (HY-A0261), Bethanechol (HY-B0406), and food[1].

References

[1] Cavanagh RL, et al. Effect of BMY-25368, a potent and long-acting histamine H2-receptor antagonist, on gastric secretion and aspirin-induced gastric lesions in the dog. Aliment Pharmacol Ther. 1989 Jun;3(3):299-313. DOI:10.1111/j.1365-2036.1989.tb00217.x

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