Biofor 389
Biofor 389 Basic information
- Product Name:
- Biofor 389
- Synonyms:
-
- Biofor 389
- 2H-1,2-Oxazin-3(4H)-one, 4-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-2-methyl-
- BF 389
- 4-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-2-methyl-1,2-oxazinan-3-one
- CAS:
- 127245-22-1
- MF:
- C20H29NO3
- MW:
- 331.45
- Mol File:
- 127245-22-1.mol
Biofor 389 Chemical Properties
- Melting point:
- 171-172 °C
- Boiling point:
- 409.2±55.0 °C(Predicted)
- Density
- 1.088±0.06 g/cm3(Predicted)
- pka
- 11.68±0.50(Predicted)
Biofor 389 Usage And Synthesis
Uses
BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research[1][2][3].
in vivo
BF389 (1-30 mg/kg, p.o., five daily oral doses) inhibits paw swelling in rats, with an ED50 of 4.9 mg/kg, indicating the anti-inflammatory activity[1].
IC 50
COX-1: 4 μg/mL (IC50); COX-2: 8 μg/mL (IC50); 5-LOX
References
[1] Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. PMID:1309875
[2] Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. DOI:10.1007/BF01987895
[3] Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. DOI:10.1073/pnas.90.24.11693
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