GEA 857
GEA 857 Basic information
- Product Name:
- GEA 857
- Synonyms:
-
- GEA 857
- L-Valine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester
- CAS:
- 120493-42-7
- MF:
- C15H22ClNO2
- MW:
- 283.79
- Mol File:
- 120493-42-7.mol
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GEA 857 Usage And Synthesis
Description
Gea 857 is a putative blocker of potassium conductance.
Uses
GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases[1].
References
[1] ?gren, et al. GEA 857, A Putative Blocker of Potassium Conductance, Enhances Muscarinic Agonist‐Evoked Responses: Dissociation from an Action on 5‐HT Mechanisms. Pharmacology & toxicology 71.2 (1992): 112-119. DOI:10.1111/j.1600-0773.1992.tb00529.x