PD 138312
PD 138312 Basic information
- Product Name:
- PD 138312
- Synonyms:
-
- PD 138312
- 7-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
- 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
- CAS:
- 107334-06-5
- MF:
- C19H23FN4O3
- MW:
- 374.41
- Mol File:
- 107334-06-5.mol
More
Less
PD 138312 Chemical Properties
- Boiling point:
- 591.5±50.0 °C(Predicted)
- Density
- 1.442±0.06 g/cm3(Predicted)
- pka
- 6.03±0.70(Predicted)
More
Less
PD 138312 Usage And Synthesis
Description
PD 138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally.