DAMNACANTHOL Chemical Properties

form 

Solid

color 

Light yellow to yellow

InChI

InChI=1S/C16H12O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-6,17-18H,7H2,1H3

InChIKey

ASFZQCLAQPBWDN-UHFFFAOYSA-N

SMILES

C1(OC)=C2C(C(=O)C3=C(C2=O)C=CC=C3)=CC(O)=C1CO

DAMNACANTHOL Usage And Synthesis

Uses

Damnacanthol is a natural product that can be isolated from Damnacanthus major[1]. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells[2].

IC 50

15-LOX

References

[1] Ayyangar N R, et al. Anthraquinone and anthrone series—XXIII: The non-identity of 1: 3: 8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal. Tetrahedron, 1959, 6(4): 331-337.
[2] Dzoyem JP, et al. Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi. Planta Med. 2016 Sep;82(14):1246-51. DOI:10.1055/s-0042-104417

DAMNACANTHOL(477-83-8)Related Product Information

• DAMNACANTHOL
• LUCIDIN