N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride Chemical Properties

Melting point:

92-93℃ (DEC.)

Density 

1.377

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Ethyl Acetate (Slightly)

pka

9.27±0.40(Predicted)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C9H11F3N2O4/c10-9(11,12)7(16)13-4-2-1-3-5-6(15)18-8(17)14-5/h5H,1-4H2,(H,13,16)(H,14,17)/t5-/m0/s1

InChIKey

KWNIHCJDDYRQFW-YFKPBYRVSA-N

SMILES

C(NCCCC[C@H]1C(=O)OC(=O)N1)(=O)C(F)(F)F

Safety Information

HS Code 

2933.79.8500

N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride Usage And Synthesis

Description

N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride is a N6-trifluoroacetylated lysine derivative that is used in the synthesis of peptides. It is a racemic mixture of L and D forms, which is hydrolyzed to form L-glutamic acid, NH4Cl, and CO2. N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride has been shown to be useful in the formation of bonds between amino acids, such as lysine and dipeptides. The compound is also used for the protection of lysine against oxidation during peptide synthesis.

Chemical Properties

White to Off-White Solid

Uses

Used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers. ?DGL polymers were prepd. through a multiple-generation scheme (up to generation 5) in a weakly acidic aq. medium by polycondensing N.vepsiln.-trifluoroacetyl-L-lysine-N-carboxyanhydride (Lys(Tfa)-NCA) onto the previous generation G(n-1) of DGL, which was used as a macroinitiator.

Uses

L-Lys(Tfa)-NCA (N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride) can be used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers.

N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride(42267-27-6)Related Product Information

• 6-(TRIFLUOROACETYLAMINO)-1-HEXANOL
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• N-6-Trifluoroacetyl-L-lysine