N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride Basic information
- Product Name:
- N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
- Synonyms:
-
- N-[4-[(4S)-2,5-dioxooxazolidin-4-yl]butyl]-2,2,2-trifluoro-acetamide
- e-Trifluoroacetyl-Lysine, NCA
- N-Trifluoroacetyl-L-lysine N-carboxyanhydride
- N-(4-(2,5-Dioxo-4-oxazolidinyl)butyl)-2,2,2-trifluoroacetamide
- N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
- L-Lysine-N-Trifluoroacetyl-N-Carboxyanhydride
- (S)-N-[4-(2,5-Dioxo-4-oxazolidinyl)butyl]-2,2,2-trifluoroacetaMide
- N-[4-[(4S)-2,5-Dioxo-4-oxazolidinyl]butyl]-2,2,2-trifluoroacetaMide
- CAS:
- 42267-27-6
- MF:
- C9H11F3N2O4
- MW:
- 268.19
- EINECS:
- 610-008-1
- Product Categories:
-
- AMINOACIDS DERIVATIVES
- Amino Acids & Derivatives
- Aromatics
- Chiral Reagents
- Heterocycles
- Mol File:
- 42267-27-6.mol
N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride Chemical Properties
- Melting point:
- 92-93℃ (DEC.)
- Density
- 1.377
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- pka
- 9.27±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C9H11F3N2O4/c10-9(11,12)7(16)13-4-2-1-3-5-6(15)18-8(17)14-5/h5H,1-4H2,(H,13,16)(H,14,17)/t5-/m0/s1
- InChIKey
- KWNIHCJDDYRQFW-YFKPBYRVSA-N
- SMILES
- C(NCCCC[C@H]1C(=O)OC(=O)N1)(=O)C(F)(F)F
N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride Usage And Synthesis
Description
N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride is a N6-trifluoroacetylated lysine derivative that is used in the synthesis of peptides. It is a racemic mixture of L and D forms, which is hydrolyzed to form L-glutamic acid, NH4Cl, and CO2. N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride has been shown to be useful in the formation of bonds between amino acids, such as lysine and dipeptides. The compound is also used for the protection of lysine against oxidation during peptide synthesis.
Chemical Properties
White to Off-White Solid
Uses
Used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers. ?DGL polymers were prepd. through a multiple-generation scheme (up to generation 5) in a weakly acidic aq. medium by polycondensing N.vepsiln.-trifluoroacetyl-L-lysine-N-carboxyanhydride (Lys(Tfa)-NCA) onto the previous generation G(n-1) of DGL, which was used as a macroinitiator.
Uses
L-Lys(Tfa)-NCA (N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride) can be used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers.
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