3-BROMO-4-HYDROXYPHENYLACETIC ACID Chemical Properties

Melting point:

105-107℃

Boiling point:

364℃

Density 

1.757

Flash point:

174℃

storage temp. 

Sealed in dry,Room Temperature

pka

4.33±0.10(Predicted)

CAS DataBase Reference

38692-80-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

HazardClass 

IRRITANT

3-BROMO-4-HYDROXYPHENYLACETIC ACID Usage And Synthesis

Synthesis

Step (b) 3-bromo-4-methoxyphenylacetic acid (14.0 g, 0.057 mol) and anhydrous dichloromethane (100 mL) were added to a 250 mL round bottom flask. The reaction mixture was degassed by nitrogen bubbling for 5 min. Subsequently, a dichloromethane solution of 1 M boron tribromide (63 mL, 0.063 mol) was added slowly and dropwise through the addition funnel. The reaction mixture was stirred at room temperature and a white solid was observed to precipitate gradually. After the reaction was carried out for 2 h, the product was separated by filtration and the collected white crystals were washed several times with dichloromethane to finally obtain 3-bromo-4-hydroxyphenylacetic acid (12 g, 92% yield).

References

[1] Patent: US2003/114457, 2003, A1
[2] Patent: WO2004/62661, 2004, A1. Location in patent: Page/Page column 28
[3] Patent: US2009/197959, 2009, A1. Location in patent: Page/Page column 14; 15

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