(2-OXOPYRROLIDIN-1-YL)ACETIC ACID Chemical Properties

Melting point:

143℃ (benzene )

Boiling point:

379.1±25.0 °C(Predicted)

Density 

1.319±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)

pka

3.75±0.10(Predicted)

form 

Solid

Appearance

Off-white to light yellow Solid

(2-OXOPYRROLIDIN-1-YL)ACETIC ACID Usage And Synthesis

Uses

(2-Oxopyrrolidin-1-yl)acetic acid is a reagent in the preparation of pyrazolopyridines as PDE4B inhibitors.

Synthesis

Benzyl (2-oxopyrrolidin-1-yl) acetate (233 mg, 1.0 mmol) was dissolved in methanol (5 mL) at 23 °C and 10 wt% Pd/C catalyst (100 mg) was added. The reaction mixture was deoxygenated using a vacuum pump and subsequently reacted under hydrogen atmosphere (using a hydrogen balloon).After 3 h, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). The combined filtrates were concentrated under reduced pressure to afford (2-oxopyrrolidin-1-yl)acetic acid (143 mg, 100% yield).

References

[1] Patent: US2006/211603, 2006, A1. Location in patent: Page/Page column 76

(2-OXOPYRROLIDIN-1-YL)ACETIC ACID(53934-76-2)Related Product Information

• (2-OXOPYRROLIDIN-1-YL)ACETIC ACID
• (2,5-DIOXO-PYRROLIDIN-1-YL)-ACETIC ACID
• 2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER
• 7A-METHYL-5-OXOHEXAHYDROPYRROLO[2,1-B][1,3]THIAZOLE-3-CARBOXYLIC ACID
• ethyl 2-oxopyrrolidine-1-acetate
• (2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETIC ACID
• FMOC-(S,S)-[PRO-LEU]-SPIROLACTAME
• 2-(3,5-DIOXO-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-4-METHYLPENTANOIC ACID
• (1,3-DIOXO-OCTAHYDRO-ISOINDOL-2-YL)-ACETIC ACID
• Piraxelate
• (1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO-2H-ISOINDOL-2-YL)ACETIC ACID
• 2-(2,5-dioxopyrrolidin-1-yl)-3-phenylpropanoic acid
• N-(5,5-Dimethyl-2-oxotetrahydro-3-furyl)succinimide
• 2-[16,18-DIOXO-17-AZAPENTACYCLO[6.6.5.0(2,7).0(9,14).0(15,19)]NONADECA-2(7),3,5,9(14),10,12-HEXAEN-17-YL]ACETIC ACID
• 2-(2,5-DIOXOPYRROLIDIN-1-YL)PROPANOIC ACID
• 2-(2,5-dioxopyrrolidin-1-yl)-4-methylpentanoic acid
• TOSLAB 17283
• AKOS BBS-00002239