4-AMINO-1-ISOPROPYL-1H-PYRAZOLE Chemical Properties

Boiling point:

234.2±13.0 °C(Predicted)

Density 

1.12±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.74±0.10(Predicted)

Appearance

Brown to reddish brown Liquid

Safety Information

HS Code 

2933199090

4-AMINO-1-ISOPROPYL-1H-PYRAZOLE Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-amino-1-isopropyl-1H-pyrazole from 1-isopropyl-4-nitro-1H-pyrazole: To a 25 mL round bottom flask was added a methanol solution (4 mL) of 1-isopropyl-4-nitro-1H-pyrazole (200 mg, 1.29 mmol, 1.00 equiv.) and palladium carbon (40 mg). Hydrogen (H2) was passed into the reaction system and the reaction was stirred for 3 hours at room temperature. Upon completion of the reaction, the solid catalyst was removed by filtration and the filtrate was concentrated in vacuum to afford 154 mg (95% yield) of 4-amino-1-isopropyl-1H-pyrazole as a pink oil.

References

[1] Patent: WO2015/48281, 2015, A1. Location in patent: Paragraph 00510; 00512
[2] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0301; 0303
[3] Patent: WO2017/4134, 2017, A1. Location in patent: Paragraph 00293
[4] Patent: WO2006/40520, 2006, A1. Location in patent: Page/Page column 123-124
[5] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 112

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