JKC-301 Chemical Properties

Boiling point:

1052.2±65.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

-15°C

pka

4.04±0.10(Predicted)

Sequence

Cyclo({d-Asp}-Pro-{d-Ile}-Leu-{d-Trp})

JKC-301 Usage And Synthesis

Uses

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].

References

[1] Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. DOI:10.1016/s0014-2999(00)00194-1
[2] Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76. DOI:10.1002/(SICI)1096-9888(200002)35:2<265::AID-JMS946>3.0.CO;2-#

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