3-bromo-1H-indazole-7-carbonitrile Chemical Properties

Boiling point:

425.3±25.0 °C(Predicted)

Density 

1.85±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

8.69±0.40(Predicted)

form 

Solid

color 

Off-white to light brown

3-bromo-1H-indazole-7-carbonitrile Usage And Synthesis

Uses

nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1].

IC 50

nNOS: 2.5 μM (IC₅₀); iNOS: 5.7 μM (IC₅₀); eNOS: 13 μM (IC₅₀)

References

[1] Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DOI:10.1016/j.bmc.2008.04.056