ANANTIN (LINEAR SEQUENCE) Chemical Properties

storage temp. 

−20°C

Sequence

Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe (Lactam bridge:Gly1-Asp8)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ANANTIN (LINEAR SEQUENCE) Usage And Synthesis

Uses

Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist[1][2].

References

[1] Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80.https://pubmed.ncbi.nlm.nih.gov/1826288/1. Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80. DOI:10.7164/antibiotics.44.172
[2] Nachshon S, et al. Effects of ANP receptor antagonists on ANP secretion from adult rat cultured atrial myocytes. Am J Physiol. 1995 Mar;268(3 Pt 1):E428-32. DOI:10.1152/ajpendo.1995.268.3.E428

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