Fmoc-α-methyl-L-Leucine Chemical Properties

Boiling point:

562.7±33.0 °C(Predicted)

Density 

1.189±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.95±0.41(Predicted)

form 

powder

color 

white

InChI

InChI=1S/C22H25NO4/c1-14(2)12-22(3,20(24)25)23-21(26)27-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t22-/m0/s1

InChIKey

LKQDQIGTIVQHMG-QFIPXVFZSA-N

SMILES

C(O)(=O)[C@](C)(CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Safety Information

Hazard Codes 

O,Xn,N

Risk Statements 

8-22-50/53

Safety Statements 

60-61

TSCA 

No

HS Code 

29225090

Fmoc-α-methyl-L-Leucine Usage And Synthesis

Description

Fmoc-α-methyl-L-Leucine is an Fmoc-protected leucine derivative that can be valuable in proteomics research and solid-phase peptide synthesis.

Chemical Properties

White powder

Uses

Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity[1].

References

[1] Caterina Bissantz, et al. Peptides as oxytocin agonists. WO2015185584A1. 2015-06-03

Fmoc-α-methyl-L-Leucine(312624-65-0)Related Product Information

• (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-fluorophenyl)-2-methylpropanoic acid
• Fmoc-α-methyl-D-4-fluorophenylalanine
• FMoc-α-Me-Ser(tBu)-OH
• FMoc-α-Me-Lys(Boc)-OH
• FMoc-α-Me-D-Phe(2-F)-OH
• FMoc-α-Me-D-Orn(Boc)-OH
• FMOC-ALPHA-METHYL-L-PHE
• FMoc-α-Me-D-Lys(Boc)-OH
• FMoc-α-Me-Orn(Boc)-OH
• (S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98%
• (R)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-2-METHYL-HEPT-6-ENOIC ACID
• (R)-N-Fmoc-2-(2'-propylenyl)alanine
• (S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-2-METHYLHEPT-6-ENOIC ACID
• Fmoc-alpha-methyl-D-leucine
• Fmoc-α-methyl-L-4-Fluorophenylalanine
• (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-fluorophenyl)-2-methylpropanoic acid
• (9H-Fluoren-9-yl)MethOxy]Carbonyl Alpha-Methyl-D-Ser(tBu)-OH
• Fmoc-alpha-methyl-L-4-bromophenylalanine