15D-PGJ2 Chemical Properties

Flash point:

-9℃

storage temp. 

-20°C

solubility 

Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml)

form 

methyl acetate solution

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/38-66-67-36

Safety Statements 

16-26-29-33-36/37/39

RIDADR 

UN 1231 3/PG 2

WGK Germany 

1

MSDS

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15D-PGJ2 Usage And Synthesis

Uses

15-Deoxy-Δ12,14-prostaglandin J2 has been used:

• to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
• as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
• as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation

Definition

ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-).

General Description

A metabolite of PGD₂ that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.

Biological Activity

Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M).

Biochem/physiol Actions

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.

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