(R)-(+)-BLEBBISTATIN O-BENZOATE Chemical Properties

Melting point:

157-159°C

Boiling point:

581.7±60.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform, Methanol

form 

Solid

pka

3.82±0.40(Predicted)

color 

Orange

(R)-(+)-BLEBBISTATIN O-BENZOATE Usage And Synthesis

Chemical Properties

Orange Solid

Uses

A derivative of Blebbistatin, a compound that blockes myosin II-dependent cell processes

Uses

(R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin (B592495). (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.