5-METHOXYGRAMINE Chemical Properties

Melting point:

123-126 °C (lit.)

Boiling point:

342.77°C (rough estimate)

Density 

1.0565 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Refrigerator (+4°C)

pka

16.70±0.30(Predicted)

BRN 

170533

CAS DataBase Reference

16620-52-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-22

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

NL7700000

F 

10

HS Code 

29339900

Toxicity

mouse,LD50,intraperitoneal,130mg/kg (130mg/kg),Psychopharmacologia Vol. 16, Pg. 385, 1970.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

5-METHOXYGRAMINE Usage And Synthesis

Chemical Properties

white to almost white crystalline powder

Uses

• ;Reactant for preparation of dopamine D2 receptor antagonists1• ;Reactant for asymmetric preparation of ethenyl(tetrahydro)carbazoledicarboxylates via gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reaction2• ;Reactant for preparation of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols as dopamine D2-like receptor ligands3• ;Reactant for preparation of substituted N-trimethoxybenzoyl indoles, indolines, and a tetrahydroquinoline via N-aroylation with trimethoxybenzoyl chloride or anhydride as antitubulin agents4• ;Reactant for preparation of in

Uses

• Reactant for preparation of dopamine D2 receptor antagonists
• Reactant for asymmetric preparation of ethenyl(tetrahydro)carbazoledicarboxylates via gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reaction
• Reactant for preparation of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols as dopamine D2-like receptor ligands
• Reactant for preparation of substituted N-trimethoxybenzoyl indoles, indolines, and a tetrahydroquinoline via N-aroylation with trimethoxybenzoyl chloride or anhydride as antitubulin agents
• Reactant for preparation of indolylmethanesulfonamide and its methoxy derivatives

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