7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt Basic information
- Product Name:
- 7-Chlorokynurenic acid sodium salt
- Synonyms:
-
- 7-Chlorokynurenic acid sodium salt
- 7-Chloro-4-hydroxyquinoline-2-carboxylicacidsodiumsalt
- 7-CKA sodium salt
- 7Chlorokynurenic acid sodium salt,7 Chlorokynurenic acid sodium salt
- 7-Chlorokynurenic acid sodium salt (mM/ml), NMDA receptor glycine site antagonist
- 7-Chlorokynurenic acid sodium salt (Aqueous Solution)
- 7-Chlorokynurenic acid sodium salt, NMDA receptor glycine site antagonist
- CAS:
- 1263094-00-3
- MF:
- C10H7ClNNaO3
- MW:
- 247.61
- Product Categories:
-
- Glutamate
- Mol File:
- 1263094-00-3.mol
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7-Chlorokynurenic acid sodium salt Chemical Properties
- storage temp.
- Desiccate at RT
- solubility
- water: 100 mM
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble in water at 100mM
- InChI
- 1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1
- InChIKey
- IFZYIORLNGNLEI-UHFFFAOYSA-M
- SMILES
- [Na+].Clc1cc2[nH]c(c[c](c2cc1)=O)C(=O)[O-]
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7-Chlorokynurenic acid sodium salt Usage And Synthesis
Uses
7-Chlorokynurenic acid sodium salt is used as a Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is also used as an NMDA receptor antagonist and inhibitor of EAAT.
Biological Activity
Primary Target
NMDA receptors
in vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].
IC 50
NMDA Receptor
storage
Desiccate at RT
7-Chlorokynurenic acid sodium saltSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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Ascent Scientific
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