Ethyl 2-bromooxazole-5-carboxylate Chemical Properties

Boiling point:

272.2±32.0 °C(Predicted)

Density 

1.617±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-2+-.0.10(Predicted)

Appearance

Off-white to yellow Solid

InChI

InChI=1S/C6H6BrNO3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3

InChIKey

VZYKDUOPMKESLS-UHFFFAOYSA-N

SMILES

O1C(C(OCC)=O)=CN=C1Br

Safety Information

HS Code 

2934999090

Ethyl 2-bromooxazole-5-carboxylate Usage And Synthesis

Uses

Ethyl 2-bromooxazole-5-carboxylate is an organic synthesis intermediate. In the synthesis of novel topoisomerase II inhibitors (such as IID432), this compound serves as a coupling substrate for the construction of the oxazole ring core structure [1].

References

[1] Olivier René, Manuel Saldivia, Maxime Dauphinais, et al. (2026). Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model. Journal of medicinal chemistry, 69(2), 1135–1153. https://doi.org/10.1021/acs.jmedchem.5c02459