tetrahydroxyl diphenylethylene-2-o-glucoside Chemical Properties

Boiling point:

715.0±60.0 °C(Predicted)

Density 

1.593

pka

8.87±0.40(Predicted)

form 

Solid

color 

White to off-white

tetrahydroxyl diphenylethylene-2-o-glucoside Usage And Synthesis

Uses

2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside (TSG) is an active product that can be extracted from Polygonum multiflorum Thunb. TSG has anti-inflammatory, antioxidative, anti-atherosclerotic, anti-apoptotic, and free radical scavenging activities, TSG is also indicated to facilitate long-term potentiation and learning and memory in both normal and pathological conditions[1][2].

Definition

ChEBI: (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. It has a role as an antioxidant, a cyclooxygenase 2 inhibitor, an anti-inflammatory agent, a cardioprotective agent, a platelet aggregation inhibitor and an apoptosis inhibitor. It is a stilbenoid, a beta-D-glucoside and a member of resorcinols.

References

[1] Y Kimura, et al. Effects of stilbene components of roots of Polygonum ssp. on liver injury in peroxidized oil-fed rats. Planta Med. 1983 Sep;49(1):51-4. DOI:10.1055/s-2007-969810
[2] Wu J, et al. Current pharmacological developments in 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG). Eur J Pharmacol. 2017 Sep 15;811:21-29. DOI:10.1016/j.ejphar.2017.05.037

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