2-CHLOR-4-TRIFLUOROMETHYL-BENZYLALCOHOL Chemical Properties

Melting point:

50-52℃

Boiling point:

227℃

Density 

1.416

Flash point:

91℃

storage temp. 

Sealed in dry,Room Temperature

pka

13.66±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2909498090

2-CHLOR-4-TRIFLUOROMETHYL-BENZYLALCOHOL Usage And Synthesis

Uses

2-Chloro-4-(trifluoromethyl)benzylalcohol

Synthesis

The general procedure for the synthesis of 2-chloro-4-trifluoromethylbenzyl alcohol from 2-chloro-4-trifluoromethylbenzoic acid was as follows: 2-chloro-4-trifluoromethylbenzoic acid (2.50 g) was added to a tetrahydrofuran solution (30 mL) containing sodium borohydride, and the reaction was stirred for 1 h at room temperature. Upon completion of the reaction, the reaction mixture was slowly poured into 1N hydrochloric acid solution and extracted with ethyl acetate. The organic phases were combined, washed sequentially with aqueous sodium bicarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with gradient elution using ethyl acetate-hexane (1:24 to 1:4, v/v) as eluent, and the target components were collected and concentrated under reduced pressure to obtain 2-chloro-4-trifluoromethylbenzenemethanol (2.23 g, yield: 96%), which was a colorless oil. Its 1H-NMR (300 MHz, CDCl3) data were as follows: δ 4.85 (2H, d, J = 9.0 Hz), 7.52-7.80 (3H, m).

References

[1] Patent: WO2007/18314, 2007, A2. Location in patent: Page/Page column 165-166
[2] Patent: EP1829863, 2007, A1
[3] Patent: WO2006/57448, 2006, A1. Location in patent: Page/Page column 163

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