Glyphosine Chemical Properties

Melting point:

263°C

Boiling point:

668.4±65.0 °C(Predicted)

Density 

1.952±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

PBS (pH: 7.2):5.0(Max Conc. mg/mL);19.01(Max Conc. mM)

form 

Solid

pka

pK1 1.42; pK2 2.10; pK3 5.02; pK4 6.40; pK5 11.19(at 25℃)

color 

White

Water Solubility 

248g/L(20 ºC)

Merck 

13,4526

BRN 

1884944

CAS DataBase Reference

2439-99-8(CAS DataBase Reference)

EPA Substance Registry System

Glyphosine (2439-99-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-2

RIDADR 

UN 3261 8/PG 3

WGK Germany 

1

RTECS 

MB9120000

HS Code 

2922.49.8000

Toxicity

LD50 orally in rats: 3925 mg/kg; dermally in rabbits: >5010 mg/kg (Ahlrichs)

MSDS

• Language:English Provider:Glyphosine
• Language:English Provider:SigmaAldrich

Glyphosine Usage And Synthesis

Description

Glyphosine was introduced in 1973 and is preferably used in sugar beets. The synthesis starting with glycine uses two equivalents of formaldehyde and of phosphorous trichloride under oxidative conditions. A second derivative of Glyphosate is a cyclic phosphaoxazole being formed from Glyphosate and formaldehyde. This compound is claimed to control the growth of some grasses without dis- coloration or phytotoxicity.

Uses

Chemical ripener; plant growth regulator.

Uses

Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.

Definition

ChEBI: A tertiary amino compound that consists of glycine bearing two N-phosphonomethyl substituents.

General Description

N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin.

Biochem/physiol Actions

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine(2439-99-8)Related Product Information

• Chlormequat chloride
• Lithium bis(trimethylsilyl)amide
• Glycine
• Methyldiethoxyphosphine
• Betaine
• Glyphosate
• METHYLPHOSPHONIC ACID
• N-(Carboxymethyl)-N-(phosphonomethyl)-glycine
• N-(2-Ethylhexyl)-5-norbornene-2,3-dicarboximide
• Piperonyl butoxide
• Sodium hydroxymethylglycinate
• Guayule
• SULFOXIDE
• Dimethyl methylphosphonate
• IMINO-BIS(METHYLPHOSPHONIC ACID)
• (Aminomethyl)phosphonic acid
• GLYPHOSATE-N-METHYL
• N-METHYLAMINOMETHYL PHOSPHONIC ACID