ECK Chemical Properties

Boiling point:

665.1±55.0 °C(Predicted)

Density 

1.464±0.06 g/cm3(Predicted)

storage temp. 

-70°C

form 

buffered aqueous solution

biological source

rabbit

Specific Activity

74-102nmol/min·mg

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 1

Storage Class

10 - Combustible liquids

ECK Usage And Synthesis

Uses

EPHA2 (ephrin receptor A2) belongs to the Eph family of receptor tyrosine kinases. It is a type I transmembrane protein, and its exoplasmic domain consists of a ligand binding domain in its N-terminal, a cysteine-rich domain, and two fibronectin type III repeats. Its cytoplasmic domain contains a juxtamembrane region, a tyrosine kinase domain, a SAM (sterile-α-motif) motif, and a PDZ-binding domain.

Biological Activity

EPHA2 binds to the ephrin-A ligand and has diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process can be reversed by ligation of EPHA2.

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