3,4-DIHYDROXY HYDROCINNAMIC ACID (L-ASPARTIC ACID DIBENZYL ESTER) AMIDE Chemical Properties

Boiling point:

727.6±60.0 °C(Predicted)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .25 mg/ml

form 

A crystalline solid

pka

9.77±0.10(Predicted)

3,4-DIHYDROXY HYDROCINNAMIC ACID (L-ASPARTIC ACID DIBENZYL ESTER) AMIDE Usage And Synthesis

Uses

LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity[1].

References

[1] Lee S, et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4677-81. DOI:10.1016/j.bmcl.2004.06.101

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