7-Bromopyrido[2,3-b]pyrazine Chemical Properties

Melting point:

161-166°C

Boiling point:

293.9±35.0 °C(Predicted)

Density 

1.758±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

solid

pka

-1.00±0.30(Predicted)

color 

Faint brown

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2933998090

7-Bromopyrido[2,3-b]pyrazine Usage And Synthesis

Synthesis

7-Bromopyrido[2,3-b]pyrazine was synthesized by reacting 2,3-diamino-5-bromopyridine (2 g, 10.6 mmol) and glyoxal (5 mL, 40% aqueous solution) in ethanol (25 mL). The reaction mixture was allowed to stand for 48 hours and then concentrated in vacuum. The resulting residue was ground with ether and dried over air to afford the target product 7-bromopyrido[2,3-b]pyrazine (2.04 g, 92% yield) as a pinkish brown solid. The structure of the product was confirmed by 1H NMR (d6-DMSO): δ 9.28 (d, 1H), 9.20 (d, 1H), 9.12 (d, 1H), 8.95 (d, 1H). LC-MS (ES+) analysis showed m/z 212 ([M+H]+) and retention time (RT) was 1.98 min.

References

[1] Patent: WO2010/52448, 2010, A2. Location in patent: Page/Page column 41-42

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