ChemicalBook > Product Catalog > Organic Chemistry > Alcohols,Phenols,Phenol alcohols > Kobophenol A
Kobophenol A
Kobophenol A Basic information
- Product Name:
- Kobophenol A
- Synonyms:
-
- Kobophenol A
- (2S,2'R,3S,3'R)-3'-(3,5-Dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)[3,4'-bibenzofuran]-6,6'-diol
- [3,4'-Bibenzofuran]-6,6'-diol, 3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-, (2S,2'R,3S,3'R)-
- Amobam Impurity 2
- CAS:
- 124027-58-3
- MF:
- C56H44O13
- MW:
- 924.94
- Mol File:
- 124027-58-3.mol
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Kobophenol A Chemical Properties
- Melting point:
- 233.5-235 °C (decomp)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- pka
- 9.25±0.10(Predicted)
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Kobophenol A Usage And Synthesis
Biological Activity
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 μM[1][2].
References
[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. [2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.
Kobophenol ASupplier
Wuhan ChemFaces Biochemical Co., Ltd.
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- 18607101326 15172504745
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EMMX Biotechnology LLC
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