Basic information Safety Supplier Related

GPRP (acetate)

Basic information Safety Supplier Related

GPRP (acetate) Basic information

Product Name:
GPRP (acetate)
Synonyms:
  • GPRP acetate (Gly-Pro-Arg-Pro acetate
  • Pefabloc FG)
  • GPRP ACETATE, >98%
  • GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%
  • GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG
  • GPRP (acetate)
  • H-Gly-Pro-Arg-Pro-OH (acetate)
  • Pefa 6003
CAS:
157009-81-9
MF:
C20H35N7O7
MW:
485.54
Mol File:
157009-81-9.mol
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GPRP (acetate) Chemical Properties

solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
Sequence
H-Gly-Pro-Arg-Pro-OH
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GPRP (acetate) Usage And Synthesis

Uses

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].

in vivo

GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality[3].

Animal Model:C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis[3]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

References

[1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
[2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
[3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007

GPRP (acetate)Supplier

MedChemexpress LLC
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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Creative Peptides
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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GPRP (acetate)(157009-81-9)Related Product Information