2-HYDRAZINOQUINOLINE Chemical Properties

Melting point:

142°C

Boiling point:

303.1±45.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in methanol.

pka

5.41±0.20(Predicted)

form 

powder to crystal

color 

Light yellow to Brown

CAS DataBase Reference

15793-77-8(CAS DataBase Reference)

EPA Substance Registry System

2(1H)-Quinolinone, hydrazone (15793-77-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-41-22

Safety Statements 

26-36/37/39-39

TSCA 

Yes

HS Code 

2933491090

MSDS

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2-HYDRAZINOQUINOLINE Usage And Synthesis

Uses

2-Hydrazinoquinoline acts as as a derivatization agent for LC-MS-based metabolomic investigation of diabetic ketoacidosis. It is used in agrochemical, pharmaceutical and dyestuff field.

Synthesis

The general procedure for the synthesis of 2-hydrazinoquinoline from 2-chloroquinoline was as follows: 21.0 g (128.4 mmol) of 2-chloroquinoline was first dissolved in 210 mL of ethanol. Subsequently, 64.3 g (1.3 mol) of hydrazine hydrate was added and the reaction mixture was stirred under reflux conditions for 16 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the precipitated solid product was collected by filtration and washed with a small amount of ethanol. After initial drying, the product was further dried under high vacuum. Finally, 14.5 g of product was obtained in 71% yield. The product was analyzed by LC-MS (Method 1): retention time Rt = 1.95 min; mass spectrum (ESIpos): m/z = 160 [M + H]+; 1H-NMR (400 MHz, DMSO-d6) data were as follows: δ= 8.08 (broad peaks, 1H), 7.87 (double peaks, 1H), 7.63 (double peaks, 1H), 7.57-7.43 (multiple peaks, 2H), 7.16 (triple peaks, 1H), 6.85 (double peaks, 1H), 4.35 (broad peaks, 2H).

References

[1] Patent: US2012/264704, 2012, A1. Location in patent: Page/Page column 17
[2] Journal of the Chemical Society, 1913, vol. 103, p. 1981
[3] Journal of the Indian Chemical Society, 1981, vol. 58, p. 840 - 843
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2006, vol. 65, # 2, p. 463 - 466
[5] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007, vol. 66, # 4-5, p. 972 - 975

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