2-METHYLNAPHTHO(2,1-D)OXAZOLE Chemical Properties

Melting point:

37 °C

Boiling point:

302°C(lit.)

Density 

1?+-.0.06 g/cm3(Predicted)

refractive index 

1.634-1.637

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

2.16±0.30(Predicted)

color 

White to Almost white

λmax

283nm(Octane)(lit.)

InChI

InChI=1S/C12H9NO/c1-8-13-11-7-6-9-4-2-3-5-10(9)12(11)14-8/h2-7H,1H3

InChIKey

JKYSRHYQAVELLH-UHFFFAOYSA-N

SMILES

O1C2=C3C(C=CC=C3)=CC=C2N=C1C

LogP

2.813 (est)

NIST Chemistry Reference

2-Methyl-1-naphthoxazole(20686-65-1)

EPA Substance Registry System

Naphth[2,1-d]oxazole, 2-methyl- (20686-65-1)

Safety Information

Safety Statements 

24/25

HS Code 

29349990

MSDS

• Language:English Provider:ACROS

2-METHYLNAPHTHO(2,1-D)OXAZOLE Usage And Synthesis

Chemical Properties

clear yellow-brown to orange-brown liquid

Synthesis

General procedure for the synthesis of 2-methylnaphtho[2,1-D]oxazoles from 2-nitro-1-naphthol and potassium thioacetate: A surfactant-mediated solvent-free scheme was used, which can also be applied to the conversion of aryl nitro compounds to aryl acetamides. This is achieved by reacting a mixture of aryl nitro compounds (1 eq.) with potassium thioacetate (4 eq.) in the presence of dry Triton-X 405 (as catalyst) at ca. 130 °C for ca. 3 hours in a solvent-free acetamidation reaction. The reaction produces the corresponding aryl acetamides with higher than 95% conversion (by HPLC and GC analysis) and selectivity. Representative results for the acetamidation of aryl nitro compounds have been summarized in Table 2. The generalized reaction formula for the acetamidation of aryl nitro compounds is shown below.

References

[1] Patent: WO2006/23763, 2006, A1. Location in patent: Page/Page column 12; 14
[2] Patent: WO2006/23763, 2006, A1. Location in patent: Page/Page column 12; 14

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