ON-013100
ON-013100 Basic information
- Product Name:
- ON-013100
- Synonyms:
-
- ON-013100
- UNII-J3I19I491A
- ON-013100;ON 013100;ON013100
- Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-
- CDK,ON-013100,ON 013100,inhibit,Inhibitor,Cyclin dependent kinase,ON013100
- (E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenol
- ON-013100, 10 mM in DMSO
- CAS:
- 865783-95-5
- MF:
- C19H22O7S
- MW:
- 394.44
- Mol File:
- 865783-95-5.mol
ON-013100 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
ON-013100 Usage And Synthesis
Uses
ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
IC 50
Cdk4/cyclin D1
References
[1] Cho SY, et al. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5;75:138-44. DOI:10.1016/j.jpba.2012.11.022
[2] Park IW, et al. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. DOI:10.1038/sj.onc.1210350
[3] Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
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