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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester

Basic information Safety Supplier Related

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester Basic information

Product Name:
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester
Synonyms:
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester
  • DOTA-GA(tBu)4
  • DOTAGA-tetra(t-Butyl ester)
  • DOTAGA-tetra (t-Bu ester)
  • 5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, α-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester
  • DOTAGA-(COOt-Bu)4
  • 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid
CAS:
306776-79-4
MF:
C35H64N4O10
MW:
700.9
Mol File:
306776-79-4.mol
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester Chemical Properties

Boiling point:
710.3±60.0 °C(Predicted)
Density 
1.081±0.06 g/cm3(Predicted)
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.52±0.10(Predicted)
color 
Pale Yellow to Dark Yellow
Stability:
Hygroscopic
InChIKey
SUAUFMLRKFUOID-UHFFFAOYSA-N
SMILES
N1(C(CCC(O)=O)C(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester Usage And Synthesis

Uses

5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid has been used in synthesis of; GdDOTAGA(C18)2: an efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes; bifunctional prochelators for coupling to bioactive peptides for radiometal labeling; DOTAGA-anhydride, building block for prepn. of DOTA-like chelating agents.

IC 50

RDC Bifunctional Chelator

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, a-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) esterSupplier

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