Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy-
Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy- Basic information
- Product Name:
- Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy-
- Synonyms:
-
- Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy-
- Anti-Heart Failure Agent 1
- AntiHeart Failure Agent 1,Anti Heart Failure Agent 1
- CAS:
- 142648-47-3
- MF:
- C11H11FN2O3S
- MW:
- 270.2800432
- Mol File:
- 142648-47-3.mol
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Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy- Chemical Properties
- Boiling point:
- 413.5±55.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 6.32±0.69(Predicted)
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Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy- Usage And Synthesis
Uses
Anti-Heart Failure Agent 1 an orally available compound suitable for the treatment of heart failure without inducing nausea, vomiting and restlessness.
in vivo
15 mg/kg of compound produces 60% increase in left ventricular contractility in anaesthetized cat. An oral dose of compound (25 mg/kg) could produce marked increases in left ventricular contractility (45%) in conscious dog[1].
References
[1] EP0482717A1
Benzo[b]thiophene-2-carboximidamide, 4-fluoro-N-hydroxy-5,6-dimethoxy-Supplier
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